The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Auteurs : Sook K. Song [Corée du Sud] ; Ji E. Lee [Corée du Sud] ; Hae-Jeong Park [Corée du Sud] ; Young H. Sohn [Corée du Sud] ; Jong Doo Lee [Corée du Sud] ; Phil Hyu Lee [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
Abstract
Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23477
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Sohn</name></author><author><name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23477</idno><idno type="url">https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000323</idno><idno type="wicri:Area/Main/Curation">000274</idno><idno type="wicri:Area/Main/Exploration">000121</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title><author><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K." last="Song">Sook K. Song</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Jeju University College of Medicine, Jeju</wicri:regionArea><wicri:noRegion>Jeju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E." last="Lee">Ji E. Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Park, Hae Eong" sort="Park, Hae Eong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Jeju University College of Medicine, Jeju</wicri:regionArea><wicri:noRegion>Jeju</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="296">296</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</idno><idno type="DOI">10.1002/mds.23477</idno><idno type="ArticleID">MDS23477</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cortical atrophy</term><term>dementia</term><term>mild cognitive impairment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K." last="Song">Sook K. Song</name></noRegion><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E." last="Lee">Ji E. Lee</name><name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><name sortKey="Park, Hae Eong" sort="Park, Hae Eong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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